full transcript

From the Ted Talk by David Baker: 5 challenges we could solve by designing new proteins

Unscramble the Blue Letters

Our acaiduuos idea is to bring biology out of the Stone Age through technological revolution in protein design. We've already shown that we can design new proteins with new shapes and functions. For example, vnaccies work by stimulating your immune sstyem to make a strong response against a pathogen. To make better vaccines, we've designed protein particles to which we can fuse proteins from pathogens, like this blue protein here, from the rptareisroy vuirs RSV. To make vaccine candidates that are literally btiisrnlg with the viral protein, we find that such vaccine candidates produce a much stronger imunme response to the virus than any previous vaccines that have been tested. This is imtanoprt because RSV is currently one of the leading causes of infant mortality worldwide. We've also designed new pniteors to break down gluten in your stomach for celiac disease and other proteins to stimulate your immune system to fight cancer. These advances are the beginning of the protein design revolution.

Open Cloze

Our _________ idea is to bring biology out of the Stone Age through technological revolution in protein design. We've already shown that we can design new proteins with new shapes and functions. For example, ________ work by stimulating your immune ______ to make a strong response against a pathogen. To make better vaccines, we've designed protein particles to which we can fuse proteins from pathogens, like this blue protein here, from the ___________ _____ RSV. To make vaccine candidates that are literally _________ with the viral protein, we find that such vaccine candidates produce a much stronger ______ response to the virus than any previous vaccines that have been tested. This is _________ because RSV is currently one of the leading causes of infant mortality worldwide. We've also designed new ________ to break down gluten in your stomach for celiac disease and other proteins to stimulate your immune system to fight cancer. These advances are the beginning of the protein design revolution.

Solution

  1. immune
  2. bristling
  3. system
  4. important
  5. proteins
  6. respiratory
  7. virus
  8. vaccines
  9. audacious

Original Text

Our audacious idea is to bring biology out of the Stone Age through technological revolution in protein design. We've already shown that we can design new proteins with new shapes and functions. For example, vaccines work by stimulating your immune system to make a strong response against a pathogen. To make better vaccines, we've designed protein particles to which we can fuse proteins from pathogens, like this blue protein here, from the respiratory virus RSV. To make vaccine candidates that are literally bristling with the viral protein, we find that such vaccine candidates produce a much stronger immune response to the virus than any previous vaccines that have been tested. This is important because RSV is currently one of the leading causes of infant mortality worldwide. We've also designed new proteins to break down gluten in your stomach for celiac disease and other proteins to stimulate your immune system to fight cancer. These advances are the beginning of the protein design revolution.

Frequently Occurring Word Combinations

ngrams of length 2

collocation frequency
protein design 7
amino acid 6
amino acids 5
immune system 3
acid sequences 3
protein folding 3
synthetic gene 3
total number 3
remarkable biological 2
acid sequence 2
stone age 2
computational protein 2
challenges today 2
designed protein 2
vaccine candidates 2
design revolution 2
bell laboratories 2
immune cells 2

ngrams of length 3

collocation frequency
amino acid sequences 3
amino acid sequence 2
protein design revolution 2

Important Words

  1. advances
  2. age
  3. audacious
  4. beginning
  5. biology
  6. blue
  7. break
  8. bring
  9. bristling
  10. cancer
  11. candidates
  12. celiac
  13. design
  14. designed
  15. disease
  16. fight
  17. find
  18. functions
  19. fuse
  20. gluten
  21. idea
  22. immune
  23. important
  24. infant
  25. leading
  26. literally
  27. mortality
  28. particles
  29. pathogen
  30. pathogens
  31. previous
  32. produce
  33. protein
  34. proteins
  35. respiratory
  36. response
  37. revolution
  38. rsv
  39. shapes
  40. shown
  41. stimulate
  42. stimulating
  43. stomach
  44. stone
  45. strong
  46. stronger
  47. system
  48. technological
  49. tested
  50. vaccine
  51. vaccines
  52. viral
  53. virus
  54. work
  55. worldwide